A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ring.

Chen Q, Pollard TD

We created two new mutants of fission yeast cofilin to investigate why cytokinesis in many organisms depends on this small actin-binding protein. These mutant cofilins bound actin monomers normally, but bound and severed ADP-actin filaments much slower than wild-type cofilin. Cells depending on mutant cofilins condensed nodes, precursors of the contractile ring, into clumps rather than rings. Starting from clumped ... [more]

Unknown Oct. 24, 2011; 0(0); [Pubmed: 22024167]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ADF1 AIP1	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Chen Q (2015)	Low	-	BioGRID	3654947
AIP1 ADF1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Chen Q (2015)	Low	-	PomBase	-

Curated By

BioGRID

Interaction Summary

ADF1

Gene Ontology Biological Process

Gene Ontology Cellular Component

AIP1