BAIT
TAB3
4921526G09Rik, Map3k7ip3, mKIAA4135, RP23-181A7.1
TGF-beta activated kinase 1/MAP3K7 binding protein 3
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Nuclear factor-kappaB (NF-kappaB) is a key transcription factor in inflammatory, anti-apoptotic and immune processes. The ubiquitin pathway is crucial in regulating the NF-kappaB pathway. We have found that the LUBAC ligase complex, composed of the two RING finger proteins HOIL-1L and HOIP, conjugates a head-to-tail-linked linear polyubiquitin chain to substrates. Here, we demonstrate that LUBAC activates the canonical NF-kappaB pathway ... [more]
Nat. Cell Biol. Feb. 01, 2009; 11(2);123-32 [Pubmed: 19136968]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Related interactions
Curated By
- BioGRID