RNF31
Gene Ontology Biological Process
- CD40 signaling pathway [IMP]
- T cell receptor signaling pathway [ISO]
- negative regulation of necroptotic process [IGI]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- protein linear polyubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IKBKB
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- I-kappaB phosphorylation [IDA, TAS]
- cellular response to tumor necrosis factor [ISO]
- neuron projection development [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of cation channel activity [IGI]
- positive regulation of cell proliferation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of sodium ion transport [IGI]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein phosphorylation [IMP, ISO]
- serine phosphorylation of STAT protein [ISO]
- signal transduction by phosphorylation [TAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- IkappaB kinase activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- receptor signaling protein serine/threonine kinase activity [TAS]
- scaffold protein binding [ISO]
- ATP binding [ISO]
- IkappaB kinase activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- receptor signaling protein serine/threonine kinase activity [TAS]
- scaffold protein binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Nuclear factor-kappaB (NF-kappaB) is a key transcription factor in inflammatory, anti-apoptotic and immune processes. The ubiquitin pathway is crucial in regulating the NF-kappaB pathway. We have found that the LUBAC ligase complex, composed of the two RING finger proteins HOIL-1L and HOIP, conjugates a head-to-tail-linked linear polyubiquitin chain to substrates. Here, we demonstrate that LUBAC activates the canonical NF-kappaB pathway ... [more]
Throughput
- Low Throughput
Additional Notes
- in the presence of overexpressed nemo
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IKBKB RNF31 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.964 | BioGRID | 2684993 |
Curated By
- BioGRID