BAIT
NCOA2
GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75
nuclear receptor coactivator 2
GO Process (7)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- cellular response to hormone stimulus [IBA]
- circadian regulation of gene expression [ISS]
- intracellular receptor signaling pathway [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of transcription, DNA-templated [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [IBA]
Homo sapiens
PREY
ATR
FCTCS, FRP1, MEC1, SCKL, SCKL1
ATR serine/threonine kinase
GO Process (14)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- DNA damage checkpoint [IDA]
- DNA repair [TAS]
- DNA replication [TAS]
- cell cycle [TAS]
- cellular response to DNA damage stimulus [TAS]
- cellular response to UV [IMP]
- cellular response to gamma radiation [IDA]
- double-strand break repair via homologous recombination [IBA]
- multicellular organismal development [TAS]
- negative regulation of DNA replication [IMP]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- protein autophosphorylation [IDA]
- replicative senescence [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.
We report our initial efforts in the analysis of endogenous nuclear receptor coactivator complexes as a research bridging strand of the Nuclear Receptor Signaling Atlas (NURSA) (www.NURSA.org). A proteomic approach is used to systematically isolate a variety of coactivator complexes using HeLa cells as a model cell line and to identify the coactivator-associated proteins with mass spectrometry. We have isolated ... [more]
Mol. Endocrinol. Oct. 01, 2005; 19(10);2451-65 [Pubmed: 16051665]
Throughput
- Low Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID