BAIT
NEDD4
NEDD4-1, RPF1, PIG53
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
GO Process (26)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- cellular response to UV [IMP]
- cytokine-mediated signaling pathway [TAS]
- development involved in symbiotic interaction [IMP]
- glucocorticoid receptor signaling pathway [IDA]
- lysosomal transport [IDA]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISS]
- neuron projection development [IEP]
- positive regulation of nucleocytoplasmic transport [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein catabolic process [IDA]
- progesterone receptor signaling pathway [IDA]
- protein K63-linked ubiquitination [ISS]
- protein targeting to lysosome [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, IMP]
- receptor catabolic process [IDA]
- receptor internalization [IDA]
- regulation of dendrite morphogenesis [ISS]
- regulation of ion transmembrane transport [IDA]
- regulation of membrane potential [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- response to calcium ion [TAS]
- transmission of virus [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
Gene Ontology Molecular Function- RNA polymerase binding [IPI]
- beta-2 adrenergic receptor binding [IDA]
- phosphoserine binding [ISS]
- phosphothreonine binding [ISS]
- proline-rich region binding [IMP, IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sodium channel inhibitor activity [IDA]
- ubiquitin binding [IDA]
- ubiquitin-protein transferase activity [IDA]
- RNA polymerase binding [IPI]
- beta-2 adrenergic receptor binding [IDA]
- phosphoserine binding [ISS]
- phosphothreonine binding [ISS]
- proline-rich region binding [IMP, IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sodium channel inhibitor activity [IDA]
- ubiquitin binding [IDA]
- ubiquitin-protein transferase activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
SNCA
NACP, alphaSYN
synuclein, alpha
GO Process (66)
GO Function (24)
GO Component (25)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- adult locomotory behavior [IGI]
- behavioral response to cocaine [ISO]
- cellular response to copper ion [ISO]
- cellular response to oxidative stress [IMP]
- dopamine biosynthetic process [IMP]
- dopamine metabolic process [IGI]
- fatty acid metabolic process [IMP]
- long-term synaptic potentiation [IMP]
- membrane organization [IMP]
- microglial cell activation [IMP]
- mitochondrial ATP synthesis coupled electron transport [IMP]
- mitochondrial membrane organization [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of dopamine metabolic process [ISO]
- negative regulation of dopamine uptake involved in synaptic transmission [ISO]
- negative regulation of exocytosis [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of microtubule polymerization [ISO]
- negative regulation of monooxygenase activity [ISO]
- negative regulation of neuron apoptotic process [IGI, ISO]
- negative regulation of norepinephrine uptake [ISO]
- negative regulation of platelet-derived growth factor receptor signaling pathway [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of serotonin uptake [ISO]
- negative regulation of thrombin receptor signaling pathway [ISO]
- negative regulation of transporter activity [ISO]
- neutral lipid metabolic process [IMP]
- oxidation-reduction process [ISO]
- phospholipid metabolic process [IMP]
- positive regulation of endocytosis [ISO]
- positive regulation of glutathione peroxidase activity [ISO]
- positive regulation of hydrogen peroxide catabolic process [ISO]
- positive regulation of inositol phosphate biosynthetic process [ISO]
- positive regulation of neurotransmitter secretion [IDA]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of receptor recycling [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- positive regulation of synaptic transmission [IMP]
- protein destabilization [ISO]
- receptor internalization [ISO]
- regulation of acyl-CoA biosynthetic process [IDA, IMP]
- regulation of dopamine secretion [IGI]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of glutamate secretion [IMP]
- regulation of locomotion [IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of macrophage activation [IMP]
- regulation of neuron apoptotic process [IMP]
- regulation of neuron death [ISO]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of neurotransmitter secretion [IGI, IMP]
- regulation of phospholipase activity [ISO]
- response to drug [IMP]
- response to interferon-gamma [ISO]
- response to interleukin-1 [ISO]
- response to iron(II) ion [ISO]
- response to lipopolysaccharide [ISO]
- response to magnesium ion [ISO]
- synapse organization [IGI]
- synaptic transmission [IGI]
- synaptic transmission, dopaminergic [IMP]
- synaptic vesicle endocytosis [IMP]
- synaptic vesicle transport [IMP]
Gene Ontology Molecular Function- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [IDA]
- beta-tubulin binding [ISO]
- calcium ion binding [ISO]
- copper ion binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [ISO]
- ferrous iron binding [ISO]
- histone binding [IDA, ISO]
- identical protein binding [IDA, ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [ISO]
- oxidoreductase activity [ISO]
- phospholipase binding [ISO]
- phospholipid binding [ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- tau protein binding [ISO]
- zinc ion binding [ISO]
- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [IDA]
- beta-tubulin binding [ISO]
- calcium ion binding [ISO]
- copper ion binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [ISO]
- ferrous iron binding [ISO]
- histone binding [IDA, ISO]
- identical protein binding [IDA, ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [ISO]
- oxidoreductase activity [ISO]
- phospholipase binding [ISO]
- phospholipid binding [ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- tau protein binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- actin cytoskeleton [ISO]
- axon [ISO]
- axon terminus [ISO]
- cell [IMP]
- cell cortex [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle membrane [ISO]
- cytoskeleton [IDA]
- cytosol [IDA, ISO]
- fibril [ISO]
- growth cone [ISO]
- inclusion body [IDA, ISO]
- intracellular membrane-bounded organelle [ISO]
- mitochondrion [IMP, ISO]
- nuclear outer membrane [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- platelet alpha granule membrane [ISO]
- ribosome [ISO]
- rough endoplasmic reticulum [ISO]
- synapse [IDA]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Ubiquitin ligase Nedd4 promotes {alpha}-synuclein degradation by the endosomal-lysosomal pathway.
α-Synuclein is an abundant brain protein that binds to lipid membranes and is involved in the recycling of presynaptic vesicles. In Parkinson disease, α-synuclein accumulates in intraneuronal inclusions often containing ubiquitin chains. Here we show that the ubiquitin ligase Nedd4, which functions in the endosomal-lysosomal pathway, robustly ubiquitinates α-synuclein, unlike ligases previously implicated in its degradation. Purified Nedd4 recognizes the ... [more]
Proc. Natl. Acad. Sci. U.S.A. Oct. 11, 2011; 108(41);17004-9 [Pubmed: 21953697]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NEDD4 SNCA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID