BAIT
SETD8
KMT5A, PR-Set7, SET07, SET8
SET domain containing (lysine methyltransferase) 8
GO Process (6)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- histone lysine methylation [IDA]
- mitotic cell cycle [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-lysine monomethylation [IDA]
- regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
TP53BP1
53BP1, p202
tumor protein p53 binding protein 1
GO Process (8)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IC]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [NAS]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.
The histone methyltransferase PR-Set7/Set8 is the sole enzyme that catalyzes monomethylation of histone H4 at K20 (H4K20me1). Previous reports document disparate evidence regarding PR-Set7 expression during the cell cycle, the biological relevance of PR-Set7 interaction with PCNA, and its role in the cell. We find that PR-Set7 is indeed undetectable during S phase and instead is detected during late G2, ... [more]
Mol. Cell Nov. 12, 2010; 40(3);364-76 [Pubmed: 21035370]
Throughput
- Low Throughput
Curated By
- BioGRID