BAIT
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
GO Process (7)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IEP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- negative regulation of NFAT protein import into nucleus [IMP]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of glycogen biosynthetic process [IDA]
- protein phosphorylation [IDA]
- smoothened signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DLST
DLTS
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
GO Process (6)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.
Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP proteins (EDVP complex). Strikingly, DYRK2 serves as a scaffold for the EDVP complex, ... [more]
Nat. Cell Biol. Apr. 01, 2009; 11(4);409-19 [Pubmed: 19287380]
Throughput
- High Throughput
Curated By
- BioGRID