BAIT

UBE3A

ANCR, AS, E6-AP, EPVE6AP, HPVE6A

ubiquitin protein ligase E3A

Human Papilloma Virus (HPV) Project

GO Process (9)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

androgen receptor signaling pathway [IBA]

brain development [TAS]

protein K48-linked ubiquitination [IDA]

protein autoubiquitination [IDA]

protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]

proteolysis [TAS]

regulation of circadian rhythm [IMP]

regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]

ubiquitin-dependent protein catabolic process [TAS]

Gene Ontology Molecular Function

protein binding [IPI]
ubiquitin-protein transferase activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IBA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

CFTR

ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, tcag7.78

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

GO Process (9)

GO Function (9)

GO Component (10)

Gene Ontology Biological Process

cellular response to cAMP [ISS]

chloride transmembrane transport [IDA, ISS, NAS, TAS]

intracellular pH elevation [ISS]

membrane hyperpolarization [ISS]

positive regulation of voltage-gated chloride channel activity [IDA]

respiratory gaseous exchange [TAS]

sperm capacitation [ISS]

transmembrane transport [TAS]

transport [TAS]

Gene Ontology Molecular Function

ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
PDZ domain binding [IDA]
bicarbonate transmembrane transporter activity [ISS]
channel-conductance-controlling ATPase activity [NAS]
chloride channel activity [IDA]
chloride channel inhibitor activity [IDA]
chloride transmembrane transporter activity [ISS]
enzyme binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

apical plasma membrane [IDA]

basolateral plasma membrane [NAS]

cell surface [IDA]

cytoplasm [IDA]

early endosome [IDA]

endoplasmic reticulum Sec complex [IDA]

extracellular vesicular exosome [IDA]

plasma membrane [IDA, TAS]

protein complex [IDA]

recycling endosome [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins.

Mishra A, Godavarthi SK, Maheshwari M, Goswami A, Jana NR

Cells are equipped with an efficient quality control system to selectively eliminate abnormally folded and damaged proteins. Initially the cell tries to refold the unfolded proteins with the help of molecular chaperones, and failure to refold leads to their degradation by the ubiquitin proteasome system. But how this proteolytic machinery recognizes the abnormally folded proteins is poorly understood. Here, we ... [more]

J. Biol. Chem. Apr. 17, 2009; 284(16);10537-45 [Pubmed: 19233847]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CFTR UBE3A	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Wang X (2006)	High	-	BioGRID	844338

Curated By

BioGRID