ARRB1
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [IDA]
- activation of MAPK activity [IDA]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [TAS]
- endocytosis [IDA]
- follicle-stimulating hormone signaling pathway [IDA]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of GTPase activity [IDA]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of interleukin-8 production [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of protein ubiquitination [ISO]
- phototransduction [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of histone H4 acetylation [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of protein ubiquitination [IMP]
- positive regulation of receptor internalization [ISO, ISS]
- positive regulation of smooth muscle cell apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor-mediated endocytosis [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [IDA, ISO, TAS]
- regulation of cAMP biosynthetic process [TAS]
- regulation of cAMP catabolic process [TAS]
- sensory perception of pain [TAS]
- sensory perception of touch [TAS]
- stress fiber assembly [ISO]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [IDA]
- G-protein coupled receptor binding [TAS]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [IMP]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [IDA]
- clathrin binding [TAS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- follicle-stimulating hormone receptor binding [IPI]
- histone acetyltransferase activity [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein phosphorylated amino acid binding [IMP]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- AP-2 adaptor complex binding [IDA]
- G-protein coupled receptor binding [TAS]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [IMP]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [IDA]
- clathrin binding [TAS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- follicle-stimulating hormone receptor binding [IPI]
- histone acetyltransferase activity [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein phosphorylated amino acid binding [IMP]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
TRPV4
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IDA]
- actin filament organization [IDA]
- calcium ion import [IDA, ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cell-cell junction assembly [ISO, ISS]
- cellular calcium ion homeostasis [ISO, ISS]
- cellular hypotonic response [ISO]
- cellular response to heat [ISO, ISS]
- cellular response to osmotic stress [ISO, ISS]
- cortical microtubule organization [IDA]
- hyperosmotic salinity response [ISO]
- hypotonic response [IDA]
- microtubule polymerization [IDA]
- negative regulation of neuron projection development [IDA]
- osmosensory signaling pathway [ISO]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- positive regulation of microtubule depolymerization [IDA]
- regulation of response to osmotic stress [ISO]
- response to osmotic stress [ISO]
- vasopressin secretion [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- actin binding [IDA]
- actin filament binding [IDA]
- alpha-tubulin binding [IDA]
- beta-tubulin binding [IDA]
- calcium channel activity [IDA, ISO]
- calmodulin binding [ISO, ISS]
- cation channel activity [IDA, ISO, ISS]
- microtubule binding [IDA]
- osmosensor activity [ISO]
- protein binding [IPI]
- protein kinase C binding [IDA]
- protein kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [IDA]
- actin filament binding [IDA]
- alpha-tubulin binding [IDA]
- beta-tubulin binding [IDA]
- calcium channel activity [IDA, ISO]
- calmodulin binding [ISO, ISS]
- cation channel activity [IDA, ISO, ISS]
- microtubule binding [IDA]
- osmosensor activity [ISO]
- protein binding [IPI]
- protein kinase C binding [IDA]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.
β-Arrestins, originally discovered to desensitize activated G protein-coupled receptors, (aka seven-transmembrane receptors, 7TMRs) also mediate 7TMR internalization and G protein-independent signaling via these receptors. More recently, several regulatory roles of β-arrestins for atypical 7TMRs and non-7TM receptors have emerged. Here, we uncover an entirely novel regulatory role of β-arrestins in cross-talk between the angiotensin receptor (AT1aR) and a member of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRPV4 ARRB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID