BAIT
NR1H2
LXR-b, LXRB, NER, NER-I, RIP15, UNR
nuclear receptor subfamily 1, group H, member 2
GO Process (16)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- gene expression [TAS]
- negative regulation of cholesterol storage [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [NAS]
- negative regulation of lipid transport [IMP]
- negative regulation of macrophage derived foam cell differentiation [IC]
- negative regulation of pinocytosis [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cholesterol efflux [IMP]
- positive regulation of cholesterol transport [IDA]
- positive regulation of fatty acid biosynthetic process [IMP]
- positive regulation of lipoprotein lipase activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of triglyceride biosynthetic process [IMP]
- regulation of cholesterol homeostasis [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- ATPase binding [IPI]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- apolipoprotein A-I receptor binding [IPI]
- protein binding [IPI]
- ATPase binding [IPI]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- apolipoprotein A-I receptor binding [IPI]
- protein binding [IPI]
Homo sapiens
PREY
PCDH17
PCDH68, PCH68
protocadherin 17
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
High throughput analysis of protein-protein interactions is an important sector of hypothesis-generating research. Using an improved and automated version of the yeast two-hybrid system, we completed a large interaction screening project with a focus on nuclear receptors and their cofactors. A total of 425 independent yeast two-hybrid cDNA library screens resulted in 6425 potential interacting protein fragments involved in 1613 ... [more]
Mol. Cell Proteomics Feb. 01, 2005; 4(2);205-13 [Pubmed: 15604093]
Throughput
- Low Throughput
Curated By
- BioGRID