BAIT
NR1I2
BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
nuclear receptor subfamily 1, group I, member 2
GO Process (12)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- drug export [IDA]
- exogenous drug catabolic process [IDA]
- gene expression [TAS]
- intracellular receptor signaling pathway [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- steroid metabolic process [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- xenobiotic metabolic process [IDA]
- xenobiotic transport [IDA]
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- drug binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- transcription coactivator activity [TAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- drug binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- transcription coactivator activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
ACTN2
CMD1AA
actinin, alpha 2
GO Process (16)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell adhesion [TAS]
- focal adhesion assembly [IMP]
- microspike assembly [IDA]
- muscle filament sliding [TAS]
- negative regulation of potassium ion transmembrane transporter activity [IMP]
- negative regulation of potassium ion transport [IMP]
- negative regulation of protein localization to cell surface [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of potassium ion transmembrane transporter activity [IDA]
- positive regulation of potassium ion transport [IDA]
- protein homotetramerization [IDA]
- regulation of apoptotic process [NAS]
- regulation of membrane potential [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
High throughput analysis of protein-protein interactions is an important sector of hypothesis-generating research. Using an improved and automated version of the yeast two-hybrid system, we completed a large interaction screening project with a focus on nuclear receptors and their cofactors. A total of 425 independent yeast two-hybrid cDNA library screens resulted in 6425 potential interacting protein fragments involved in 1613 ... [more]
Mol. Cell Proteomics Feb. 01, 2005; 4(2);205-13 [Pubmed: 15604093]
Throughput
- Low Throughput
Curated By
- BioGRID