BAIT

NR1I3

CAR, CAR1, MB67

nuclear receptor subfamily 1, group I, member 3

GO Process (6)

GO Function (7)

GO Component (3)

Gene Ontology Biological Process

androgen receptor signaling pathway [TAS]

gene expression [TAS]

intracellular receptor signaling pathway [TAS]

positive regulation of transcription from RNA polymerase II promoter [IDA]

signal transduction [TAS]

transcription initiation from RNA polymerase II promoter [TAS]

Gene Ontology Molecular Function

DNA binding [TAS]
RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
androgen receptor activity [TAS]
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
sequence-specific DNA binding transcription factor activity [TAS]
transcription coactivator activity [TAS]

Gene Ontology Cellular Component

cytoplasm [ISS]

nucleoplasm [IDA, TAS]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

FTH1

FHC, FTH, FTHL6, HFE5, PIG15, PLIF, OK/SW-cl.84

ferritin, heavy polypeptide 1

GO Process (8)

GO Function (2)

GO Component (4)

Gene Ontology Biological Process

cellular iron ion homeostasis [TAS]

immune response [ISS]

intracellular sequestering of iron ion [IDA]

membrane organization [TAS]

negative regulation of cell proliferation [ISS]

negative regulation of fibroblast proliferation [IDA]

post-Golgi vesicle-mediated transport [TAS]

transmembrane transport [TAS]

Gene Ontology Molecular Function

iron ion binding [TAS]
protein binding [IPI]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

intracellular ferritin complex [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.

Albers M, Kranz H, Kober I, Kaiser C, Klink M, Suckow J, Kern R, Koegl M

High throughput analysis of protein-protein interactions is an important sector of hypothesis-generating research. Using an improved and automated version of the yeast two-hybrid system, we completed a large interaction screening project with a focus on nuclear receptors and their cofactors. A total of 425 independent yeast two-hybrid cDNA library screens resulted in 6425 potential interacting protein fragments involved in 1613 ... [more]

Mol. Cell Proteomics Feb. 01, 2005; 4(2);205-13 [Pubmed: 15604093]

Throughput

Low Throughput

Curated By

BioGRID