BAIT
TERF2IP
DRIP5, RAP1, PP8000
telomeric repeat binding factor 2, interacting protein
GO Process (11)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of DNA recombination at telomere [ISS]
- negative regulation of telomere maintenance [IDA, IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- positive regulation of NF-kappaB transcription factor activity [ISS]
- protection from non-homologous end joining at telomere [IMP, ISS]
- protein localization to chromosome, telomeric region [IMP]
- regulation of double-strand break repair via homologous recombination [ISS]
- regulation of transcription, DNA-templated [ISS]
- telomere maintenance [IDA, TAS]
- telomere maintenance via telomerase [TAS]
- telomere maintenance via telomere lengthening [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPA4
APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
heat shock 70kDa protein 4
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
In mammalian cells, telomere-binding proteins TRF1 and TRF2 play crucial roles in telomere biology. They interact with several other telomere regulators including TIN2, PTOP, POT1, and RAP1 to ensure proper maintenance of telomeres. TRF1 and TRF2 are believed to exert distinct functions. TRF1 forms a complex with TIN2, PTOP, and POT1 and regulates telomere length, whereas TRF2 mediates t-loop formation ... [more]
J. Biol. Chem. Dec. 03, 2004; 279(49);51338-42 [Pubmed: 15383534]
Throughput
- Low Throughput
Curated By
- BioGRID