BAIT
DYNLL1
Dlc8, Dnclc1, Pin
dynein light chain LC8-type 1
GO Process (5)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LTF
GIG12, HEL110, HLF2, LF
lactotransferrin
GO Process (25)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- antibacterial humoral response [IDA]
- antifungal humoral response [IDA]
- bone morphogenesis [IDA]
- humoral immune response [TAS]
- innate immune response in mucosa [IDA]
- interaction with host [TAS]
- iron assimilation by chelation and transport [TAS]
- negative regulation of apoptotic process [ISS]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of osteoclast development [ISS]
- negative regulation of single-species biofilm formation in or on host organism [IDA]
- negative regulation of tumor necrosis factor (ligand) superfamily member 11 production [ISS]
- phagosome maturation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of bone mineralization involved in bone maturation [ISS]
- positive regulation of chondrocyte proliferation [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of osteoblast proliferation [IDA]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of toll-like receptor 4 signaling pathway [IMP]
- regulation of cytokine production [IDA]
- regulation of tumor necrosis factor production [IDA]
- response to host immune response [TAS]
- retina homeostasis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Chromosome segregation and cell division are essential, highly ordered processes that depend on numerous protein complexes. Results from recent RNA interference screens indicate that the identity and composition of these protein complexes is incompletely understood. Using gene tagging on bacterial artificial chromosomes, protein localization, and tandem-affinity purification-mass spectrometry, the MitoCheck consortium has analyzed about 100 human protein complexes, many of ... [more]
Science Apr. 30, 2010; 328(5978);593-9 [Pubmed: 20360068]
Throughput
- High Throughput
Curated By
- BioGRID