BAIT
ATM
AI256621, C030026E19Rik
ataxia telangiectasia mutated
GO Process (35)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- DNA damage induced protein phosphorylation [ISO]
- DNA repair [IDA, IMP]
- V(D)J recombination [IGI]
- brain development [IGI]
- cell cycle arrest [ISO]
- cellular response to DNA damage stimulus [ISO, TAS]
- cellular response to gamma radiation [ISO]
- double-strand break repair via homologous recombination [IBA]
- female gamete generation [IMP]
- heart development [IGI]
- histone mRNA catabolic process [ISO]
- histone phosphorylation [ISO]
- histone-serine phosphorylation [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, IMP]
- lipoprotein catabolic process [IGI]
- mitotic spindle assembly checkpoint [ISO]
- negative regulation of B cell proliferation [ISO]
- neuron apoptotic process [IGI]
- oocyte development [IMP]
- peptidyl-serine phosphorylation [ISO]
- phosphatidylinositol phosphorylation [ISO]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [IGI]
- pre-B cell allelic exclusion [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of cell cycle [ISO]
- replicative senescence [ISO]
- response to hypoxia [ISO]
- response to ionizing radiation [IGI, ISO]
- signal transduction involved in mitotic G2 DNA damage checkpoint [ISO]
- somitogenesis [IGI]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [ISO]
- DNA-dependent protein kinase activity [ISO]
- histone serine kinase activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IBA, ISO]
- protein kinase activity [IDA, TAS]
- protein serine/threonine kinase activity [ISO]
- 1-phosphatidylinositol-3-kinase activity [ISO]
- DNA-dependent protein kinase activity [ISO]
- histone serine kinase activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IBA, ISO]
- protein kinase activity [IDA, TAS]
- protein serine/threonine kinase activity [ISO]
Mus musculus
PREY
LMNB1
ADLD, LMN, LMN2, LMNB
lamin B1
GO Process (2)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Chromosome segregation and cell division are essential, highly ordered processes that depend on numerous protein complexes. Results from recent RNA interference screens indicate that the identity and composition of these protein complexes is incompletely understood. Using gene tagging on bacterial artificial chromosomes, protein localization, and tandem-affinity purification-mass spectrometry, the MitoCheck consortium has analyzed about 100 human protein complexes, many of ... [more]
Science Apr. 30, 2010; 328(5978);593-9 [Pubmed: 20360068]
Throughput
- High Throughput
Curated By
- BioGRID