BAIT
XPO1
AA420417, Crm1, Exp1, RP23-305E10.1
exportin 1, CRM1 homolog (yeast)
GO Process (8)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- protein export from nucleus [IDA, IMP, ISO]
- protein localization to nucleus [IMP]
- regulation of centrosome duplication [IMP]
- regulation of protein catabolic process [IMP]
- regulation of protein export from nucleus [IMP]
- ribosomal large subunit export from nucleus [ISO]
- ribosomal small subunit export from nucleus [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
XDH
XO, XOR
xanthine dehydrogenase
GO Process (15)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of endothelial cell differentiation [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of vascular endothelial growth factor signaling pathway [IDA]
- negative regulation of vasculogenesis [IDA]
- nucleobase-containing small molecule metabolic process [TAS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- purine nucleobase metabolic process [TAS]
- purine nucleotide catabolic process [TAS]
- small molecule metabolic process [TAS]
- xanthine catabolic process [IDA]
Gene Ontology Molecular Function- 2 iron, 2 sulfur cluster binding [IDA]
- flavin adenine dinucleotide binding [IDA]
- molybdopterin cofactor binding [IDA]
- oxidoreductase activity, acting on the aldehyde or oxo group of donors [IBA]
- protein homodimerization activity [IPI]
- xanthine dehydrogenase activity [IDA]
- xanthine oxidase activity [EXP, IDA]
- 2 iron, 2 sulfur cluster binding [IDA]
- flavin adenine dinucleotide binding [IDA]
- molybdopterin cofactor binding [IDA]
- oxidoreductase activity, acting on the aldehyde or oxo group of donors [IBA]
- protein homodimerization activity [IPI]
- xanthine dehydrogenase activity [IDA]
- xanthine oxidase activity [EXP, IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Chromosome segregation and cell division are essential, highly ordered processes that depend on numerous protein complexes. Results from recent RNA interference screens indicate that the identity and composition of these protein complexes is incompletely understood. Using gene tagging on bacterial artificial chromosomes, protein localization, and tandem-affinity purification-mass spectrometry, the MitoCheck consortium has analyzed about 100 human protein complexes, many of ... [more]
Science Apr. 30, 2010; 328(5978);593-9 [Pubmed: 20360068]
Throughput
- High Throughput
Curated By
- BioGRID