BAIT
MAD2L1
AA673185, MAD2
MAD2 mitotic arrest deficient-like 1
GO Process (9)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- mitotic cell cycle checkpoint [ISO]
- mitotic sister chromatid segregation [IMP]
- mitotic spindle assembly checkpoint [IMP, ISA]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of mitotic anaphase-promoting complex activity [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of mitotic metaphase/anaphase transition [TAS]
- negative regulation of protein catabolic process [ISO]
- positive regulation of mitotic cell cycle spindle assembly checkpoint [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ANAPC1
APC1, MCPR, TSG24
anaphase promoting complex subunit 1
GO Process (7)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein K11-linked ubiquitination [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Chromosome segregation and cell division are essential, highly ordered processes that depend on numerous protein complexes. Results from recent RNA interference screens indicate that the identity and composition of these protein complexes is incompletely understood. Using gene tagging on bacterial artificial chromosomes, protein localization, and tandem-affinity purification-mass spectrometry, the MitoCheck consortium has analyzed about 100 human protein complexes, many of ... [more]
Science Apr. 30, 2010; 328(5978);593-9 [Pubmed: 20360068]
Throughput
- High Throughput
Curated By
- BioGRID