VPS13
Gene Ontology Biological Process
Gene Ontology Cellular Component
CBF1
Gene Ontology Biological Process
- chromatin remodeling [IDA, IMP]
- chromosome segregation [IGI, IMP]
- negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription from RNA polymerase II promoter in response to methionine [IMP]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IMP, IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II repressing transcription factor binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IMP]
- centromeric DNA binding [IDA]
- sequence-specific DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IMP, IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II repressing transcription factor binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IMP]
- centromeric DNA binding [IDA]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria.
To broadly explore mitochondrial structure and function as well as the communication of mitochondria with other cellular pathways, we constructed a quantitative, high-density genetic interaction map (the MITO-MAP) in Saccharomyces cerevisiae. The MITO-MAP provides a comprehensive view of mitochondrial function including insights into the activity of uncharacterized mitochondrial proteins and the functional connection between mitochondria and the ER. The MITO-MAP ... [more]
Quantitative Score
- -5.169462944 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score >= 2.0 for positive interactions (epistatic or suppressor interactions) and S score <= -2.5 for negative interactions (synthetic sick/lethal interactions). The authors constructed a mitochondrial-focused genetic interaction map (the MITO-MAP).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CBF1 VPS13 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1454 | BioGRID | 2139186 |
Curated By
- BioGRID