BAIT
INSIG2
insulin induced gene 2
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DSP
DCWHKTA, DP, DPI, DPII
desmoplakin
GO Process (12)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- apoptotic process [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- desmosome organization [ISS]
- epidermis development [TAS]
- intermediate filament organization [ISS]
- keratinocyte differentiation [IDA]
- peptide cross-linking [IDA]
- protein localization to adherens junction [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular compact myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes.
Polytopic membrane proteins subjected to endoplasmic reticulum (ER)-associated degradation are extracted from membranes and targeted to proteasomes for destruction. The extraction mechanism is poorly understood. One polytopic ER protein subjected to ER-associated degradation is Insig-1, a negative regulator of cholesterol synthesis. Insig-1 is rapidly degraded by proteasomes when cells are depleted of cholesterol, and its degradation is inhibited when sterols ... [more]
J. Biol. Chem. Dec. 11, 2009; 284(50);34889-900 [Pubmed: 19815544]
Throughput
- High Throughput
Curated By
- BioGRID