CDK4
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- circadian rhythm [IEP]
- lens development in camera-type eye [IEP]
- negative regulation of cell cycle arrest [ISO, ISS]
- organ regeneration [IEP]
- positive regulation of G2/M transition of mitotic cell cycle [ISO, ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cell size [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of translation [IMP]
- protein phosphorylation [ISO]
- regulation of cell cycle [ISO]
- regulation of cell proliferation [ISO]
- regulation of gene expression [ISO]
- response to drug [ISO]
- response to hyperoxia [IEP]
- response to lead ion [IMP]
- response to organic substance [IMP]
- response to testosterone [IDA]
- response to toxic substance [IEP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RUNX3
Gene Ontology Biological Process
- axon guidance [ISO]
- cell maturation [ISO]
- chondrocyte differentiation [ISO]
- hair follicle morphogenesis [ISO]
- interferon-gamma production [ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of cell cycle [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- neuron projection development [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- protein phosphorylation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation.
In chondrocytes, PTHrP maintains them in a proliferative state and prevents premature hypertrophy. The mechanism by which PTHrP does this is not fully understood. Both Runx2 and Runx3 are required for chondrocyte maturation. We recently demonstrated that cyclin D1 induces Runx2 protein phosphorylation and degradation. In the present studies, we tested the hypothesis that PTHrP regulates both Runx2 and Runx3 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RUNX3 CDK4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID