BAIT

FCP1

L000003350, YMR277W
Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

CIN8

KSL2, SDS15, kinesin motor protein CIN8, L000000340, YEL061C
Kinesin motor protein; involved in mitotic spindle assembly and chromosome segregation
Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Cell Cycle Regulators Interact with Pathways that Modulate Microtubule Stability in Yeast.

Shohat-Tal A, Eshel D

The integrity of mitosis is dependent upon strict regulation of microtubule stability and dynamics. Although much information has been accumulated on regulators of the microtubule cytoskeleton, our knowledge of the specific pathways involved is still limited. Here we designed genetic screens to identify regulators of microtubule stability that are dispensable in the wild-type yet become essential under microtubule disrupting conditions. ... [more]

Unknown Oct. 28, 2011; 0(0); [Pubmed: 22037179]

Throughput

  • Low Throughput

Ontology Terms

  • heat sensitivity (APO:0000147)
  • resistance to chemicals (APO:0000087)
  • inviable (APO:0000112)

Additional Notes

  • cin8-3 mutation causes lethality at 35 degrees and increased sensitivity to thiabendazole in kip1 swi6 mutant overexpressing FCP1

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CIN8 FCP1
Dosage Rescue
Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Low-BioGRID
589938
CIN8 FCP1
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
589946

Curated By

  • BioGRID