CACNA1C
Gene Ontology Biological Process
- adult walking behavior [ISO]
- calcium ion import [IMP]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IMP, ISO]
- calcium ion-dependent exocytosis [ISO]
- cellular calcium ion homeostasis [ISO]
- glucose homeostasis [ISO]
- growth hormone secretion [ISO]
- insulin secretion [ISO]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- regulation of blood pressure [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of organ growth [ISO]
- regulation of vasoconstriction [ISO]
- smooth muscle contraction [ISO]
- smooth muscle contraction involved in micturition [ISO]
- synaptic transmission [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- high voltage-gated calcium channel activity [IDA, IMP]
- ion channel binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein phosphatase 2A binding [IPI]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- high voltage-gated calcium channel activity [IDA, IMP]
- ion channel binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein phosphatase 2A binding [IPI]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
Gene Ontology Cellular Component
- T-tubule [IDA, TAS]
- Z disc [IDA, ISO]
- caveolar macromolecular signaling complex [ISO]
- cell [ISO]
- cytoplasm [ISO]
- dendrite [IDA]
- dendritic shaft [ISO]
- integral component of membrane [ISO]
- membrane [IDA, ISO]
- neuronal cell body [IDA, ISO]
- nucleus [IDA]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- presynaptic membrane [IDA]
- protein complex [IDA]
- sarcolemma [IDA]
- voltage-gated calcium channel complex [IC, IDA, ISO, TAS]
VCP
Gene Ontology Biological Process
- ATP catabolic process [IDA, IMP]
- ER to Golgi vesicle-mediated transport [IMP]
- ER-associated ubiquitin-dependent protein catabolic process [ISO, ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- aggresome assembly [ISO]
- cellular response to DNA damage stimulus [ISO, ISS]
- double-strand break repair [ISO, ISS]
- positive regulation of Lys63-specific deubiquitinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP, ISO]
- positive regulation of protein K63-linked deubiquitination [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein N-linked glycosylation via asparagine [ISO, ISS]
- protein hexamerization [IDA]
- protein homooligomerization [IDA]
- protein ubiquitination [ISO, ISS]
- retrograde protein transport, ER to cytosol [ISO]
- translesion synthesis [ISO, ISS]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- ADP binding [IMP]
- ATP binding [IDA, IMP]
- ATPase activity [IDA, IMP]
- deubiquitinase activator activity [ISO]
- identical protein binding [IDA]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [IDA]
- ubiquitin-specific protease binding [ISO]
- ADP binding [IMP]
- ATP binding [IDA, IMP]
- ATPase activity [IDA, IMP]
- deubiquitinase activator activity [ISO]
- identical protein binding [IDA]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [IDA]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Hrd1p ubiquitin ligase complex [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [IDA]
- lipid particle [ISO]
- myelin sheath [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- proteasome complex [ISO]
- protein complex [ISO]
- site of double-strand break [ISO, ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels.
It is well established that the auxiliary Cavβ subunit regulates calcium channel density in the plasma membrane, but the cellular mechanism by which this occurs has remained unclear. We found that the Cavβ subunit increased membrane expression of Cav1.2 channels by preventing the entry of the channels into the endoplasmic reticulum-associated protein degradation (ERAD) complex. Without Cavβ, Cav1.2 channels underwent ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID