ULP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
SCS2
Gene Ontology Biological Process
- chromatin silencing at telomere [IGI, IMP]
- endoplasmic reticulum inheritance [IGI, IMP]
- endoplasmic reticulum membrane organization [IGI]
- endoplasmic reticulum polarization [IDA]
- negative regulation of transcription factor import into nucleus [IMP, IPI]
- phospholipid biosynthetic process [IGI, IMP]
- regulation of intracellular lipid transport [IMP]
- regulation of phosphatidylinositol dephosphorylation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Desumoylation of the ER Membrane VAP Protein Scs2 by Ulp1 and SUMO Regulation of the Inositol Synthesis Pathway.
Post-translational protein modification by the ubiquitin-like SUMO protein is critical to eukaryotic cell regulation, but much remains unknown regarding its operation and substrates. Here we report that specific mutations in the Saccharomyces cerevisiae Ulp1 SUMO protease, including its coiled-coil (CC) domain, lead to the accumulation of distinct sumoylated proteins in vivo. A prominent ∼50 kDa sumoylated protein accumulates in a ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: rna accumulation (APO:0000224)
Additional Notes
- INO1 induction defect more severe in double mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SCS2 ULP2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 590033 |
Curated By
- BioGRID