CDKN1B
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- G1/S transition of mitotic cell cycle [IDA, TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- autophagic cell death [IDA]
- cell cycle arrest [IMP]
- cellular response to lithium ion [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- mitotic cell cycle [TAS]
- mitotic cell cycle arrest [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of kinase activity [IDA]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of phosphorylation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell death [IDA]
- positive regulation of protein catabolic process [IDA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIN1
Gene Ontology Biological Process
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of cell motility [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of cell growth involved in cardiac muscle cell development [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein peptidyl-prolyl isomerization [ISO]
- regulation of cell proliferation [IMP]
- regulation of cytokinesis [IMP, ISO]
- regulation of pathway-restricted SMAD protein phosphorylation [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process.
The cis-trans peptidylprolyl isomerase Pin1 plays a critical role in regulating a subset of phosphoproteins by catalyzing conformational changes on the phosphorylated Ser/Thr-Pro motifs. The phosphorylation-directed ubiquitination is one of the major mechanisms to regulate the abundance of p27(Kip1). In this study, we demonstrate that Pin1 catalyzes the cis-trans conformational changes of p27(Kip1) and further mediates its stability through the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID