PPP1CC
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EIF2B5
Gene Ontology Biological Process
- astrocyte development [ISO, ISS]
- astrocyte differentiation [ISO, ISS]
- cellular response to drug [ISO, ISS]
- myelination [ISO, ISS]
- negative regulation of translational initiation in response to stress [IMP]
- oligodendrocyte development [ISO, ISS]
- ovarian follicle development [ISO, ISS]
- positive regulation of GTPase activity [IDA, IMP, ISO, ISS]
- positive regulation of translational initiation [ISS]
- regulation of translation [IMP]
- response to endoplasmic reticulum stress [ISO, ISS]
- response to glucose [IDA]
- response to heat [IDA, ISO, ISS]
- response to peptide hormone [IDA]
- translational initiation [ISO, ISS, TAS]
Gene Ontology Molecular Function
Biochemical Activity (Dephosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells.
We have previously demonstrated that insulin-like growth factor 1 (IGF1) induces eukaryotic initiation factor 2B (eIF2B) activation in neuronal cells through the phosphatidylinositol 3 kinase/glycogen synthase kinase 3 pathway as well as by activation of the mitogen-activated protein kinase (MAPK)-activating kinase (MEK)/MAPK signaling pathway (Quevedo, C., Alcazar, A., and Salinas, M. (2000) J. Biol. Chem. 275, 19192-19197). This paper addresses ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID