BAIT
ARAP1
CENTD2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- actin filament reorganization involved in cell cycle [TAS]
- negative regulation of stress fiber assembly [IMP]
- positive regulation of Cdc42 GTPase activity [IDA]
- positive regulation of filopodium assembly [IMP]
- regulation of cell shape [IMP]
- regulation of cellular component movement [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TP53BP1
53BP1, p202
tumor protein p53 binding protein 1
GO Process (8)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IC]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [NAS]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking.
ARAP1 is an Arf (ADP-ribosylation factor)-directed GAP (GTPase-activating protein) that inhibits the trafficking of EGFR (epidermal growth factor receptor) to the early endosome. To further understand the function of ARAP1, we sought to identify proteins that interact with ARAP1.Here we report that ARAP1 associates with the CIN85 (Cbl-interacting protein of 85 kDa). Arg86 and Arg90 of ARAP1 and the SH3 ... [more]
Biol. Cell Apr. 01, 2011; 103(4);171-84 [Pubmed: 21275903]
Throughput
- High Throughput
Curated By
- BioGRID