BAIT
HLA-DRB5
HLA-DRB, hCG_1998957
major histocompatibility complex, class II, DR beta 5
GO Process (17)
GO Function (1)
GO Component (15)
Gene Ontology Biological Process
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- T-helper 1 type immune response [ISS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cytokine-mediated signaling pathway [TAS]
- detection of bacterium [ISS]
- humoral immune response mediated by circulating immunoglobulin [ISS]
- immune response [ISS]
- immunoglobulin production involved in immunoglobulin mediated immune response [ISS]
- inflammatory response to antigenic stimulus [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of T cell proliferation [ISS]
- negative regulation of interferon-gamma production [ISS]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- protein tetramerization [ISS]
- regulation of interleukin-10 secretion [ISS]
- regulation of interleukin-4 production [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi membrane [TAS]
- MHC class II protein complex [ISS]
- clathrin-coated endocytic vesicle membrane [TAS]
- endocytic vesicle membrane [TAS]
- external side of plasma membrane [ISS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- late endosome membrane [IDA]
- lysosomal membrane [IDA, TAS]
- membrane [IDA]
- plasma membrane [TAS]
- trans-Golgi network membrane [TAS]
- transport vesicle membrane [TAS]
Homo sapiens
PREY
ATP1B1
ATP1B
ATPase, Na+/K+ transporting, beta 1 polypeptide
GO Process (25)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cardiac muscle contraction [ISS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular calcium ion homeostasis [ISS]
- cellular potassium ion homeostasis [IDA]
- cellular sodium ion homeostasis [IDA]
- ion transmembrane transport [TAS]
- leukocyte migration [TAS]
- membrane repolarization [IDA]
- membrane repolarization during cardiac muscle cell action potential [IC]
- positive regulation of ATP catabolic process [IDA]
- positive regulation of ATPase activity [IDA]
- positive regulation of calcium:sodium antiporter activity [ISS]
- positive regulation of potassium ion import [IDA]
- positive regulation of potassium ion transmembrane transporter activity [IDA]
- positive regulation of sodium ion export from cell [IDA]
- potassium ion import [IDA]
- protein localization to plasma membrane [IDA]
- protein stabilization [IDA, ISS]
- protein transport into plasma membrane raft [TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [ISS]
- regulation of gene expression [ISS]
- relaxation of cardiac muscle [ISS]
- sodium ion export from cell [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Professional antigen-presenting cells secrete major histocompatibility complex class II (MHC II) carrying exosomes with unclear physiological function(s). Exosomes are first generated as the intraluminal vesicles (ILVs) of a specific type of multivesicular body, and are then secreted by fusion of this compartment with the plasma membrane. We have previously shown that in contrast to the sorting of MHC II at ... [more]
Immunol. Cell Biol. May. 12, 2010; 88(8);851-6 [Pubmed: 20458337]
Throughput
- High Throughput
Curated By
- BioGRID