BAIT
DISC1
C1orf136, SCZD9, RP4-730B13.1
disrupted in schizophrenia 1
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AKAP6
ADAP100, ADAP6, AKAP100, PRKA6, mAKAP
A kinase (PRKA) anchor protein 6
GO Process (19)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- action potential [IC]
- cAMP-mediated signaling [NAS]
- cellular response to cAMP [IDA]
- cellular response to cytokine stimulus [ISS]
- intracellular signal transduction [IBA]
- negative regulation of cAMP biosynthetic process [ISS]
- positive regulation of NFAT protein import into nucleus [ISS]
- positive regulation of calcineurin-NFAT signaling cascade [ISS]
- positive regulation of cell growth [ISS]
- positive regulation of cell growth involved in cardiac muscle cell development [ISS]
- positive regulation of delayed rectifier potassium channel activity [IDA]
- positive regulation of potassium ion transmembrane transport [IDA]
- positive regulation of protein phosphatase type 2B activity [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- protein targeting [NAS]
- regulation of membrane repolarization [IDA]
- regulation of protein kinase A signaling [ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with cognitive deficits in both schizophrenics and the normal ageing population. In this study, we have generated a network of protein-protein interactions (PPIs) around DISC1. This has been achieved by utilising iterative yeast-two hybrid (Y2H) screens, combined with detailed pathway and functional analysis. This so-called 'DISC1 interactome' contains many ... [more]
Mol. Psychiatry Jan. 01, 2007; 12(1);74-86 [Pubmed: 17043677]
Throughput
- Low Throughput
Curated By
- BioGRID