TRAF2
Gene Ontology Biological Process
- activation of NF-kappaB-inducing kinase activity [ISO]
- cellular protein complex assembly [IDA]
- cellular response to nitric oxide [IMP]
- negative regulation of apoptotic process [NAS]
- negative regulation of glial cell apoptotic process [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of protein homodimerization activity [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- programmed necrotic cell death [IMP]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein catabolic process [IMP]
- protein complex assembly [ISO]
- protein heterooligomerization [ISO]
- protein homotrimerization [ISO]
- regulation of JNK cascade [IDA]
- regulation of apoptotic process [ISO]
- regulation of immunoglobulin secretion [IMP]
- signal transduction [IDA]
- tumor necrosis factor-mediated signaling pathway [ISO]
Gene Ontology Molecular Function- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Gene Ontology Cellular Component
UBE2N
Gene Ontology Biological Process
- DNA double-strand break processing [ISO]
- T cell receptor signaling pathway [ISO, ISS]
- double-strand break repair via homologous recombination [ISO]
- histone ubiquitination [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of histone modification [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- postreplication repair [IBA, ISO]
- protein K63-linked ubiquitination [IBA, ISO]
- protein ubiquitination [ISO]
- regulation of histone ubiquitination [ISO]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes.
A20 negatively regulates inflammation by inhibiting the nuclear factor kappaB (NF-kappaB) transcription factor in the tumor necrosis factor-receptor (TNFR) and Toll-like receptor (TLR) pathways. A20 contains deubiquitinase and E3 ligase domains and thus has been proposed to function as a ubiquitin-editing enzyme downstream of TNFR1 by inactivating ubiquitinated RIP1. However, it remains unclear how A20 terminates NF-kappaB signaling downstream of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRAF2 UBE2N | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID