UBE2D3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TNFAIP3
Gene Ontology Biological Process
- B-1 B cell homeostasis [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to lipopolysaccharide [ISO]
- establishment of protein localization to vacuole [IDA]
- marginal zone B cell differentiation [NAS]
- negative regulation of B cell activation [IDA]
- negative regulation of CD40 signaling pathway [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of autophagy [NAS]
- negative regulation of cell death [IMP]
- negative regulation of chronic inflammatory response [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO, NAS]
- negative regulation of granuloma formation [NAS]
- negative regulation of heterotypic cell-cell adhesion [NAS]
- negative regulation of inflammatory response [IDA, IMP]
- negative regulation of innate immune response [IMP]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-2 production [ISO]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [IMP]
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of toll-like receptor 3 signaling pathway [ISO]
- negative regulation of toll-like receptor 5 signaling pathway [IDA]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of cellular protein catabolic process [IDA]
- positive regulation of hepatocyte proliferation [IDA]
- positive regulation of protein catabolic process [ISO]
- protein K11-linked deubiquitination [ISO]
- protein K48-linked deubiquitination [ISO]
- protein K48-linked ubiquitination [ISO]
- protein K63-linked deubiquitination [IDA, ISO]
- protein deubiquitination [IDA]
- proteolysis [ISO]
- regulation of germinal center formation [IMP]
- regulation of immunoglobulin production [IC]
- regulation of innate immune response [IC]
- response to molecule of bacterial origin [IDA, ISO]
- response to muramyl dipeptide [IMP]
- response to wounding [NAS]
- tolerance induction to lipopolysaccharide [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes.
A20 negatively regulates inflammation by inhibiting the nuclear factor kappaB (NF-kappaB) transcription factor in the tumor necrosis factor-receptor (TNFR) and Toll-like receptor (TLR) pathways. A20 contains deubiquitinase and E3 ligase domains and thus has been proposed to function as a ubiquitin-editing enzyme downstream of TNFR1 by inactivating ubiquitinated RIP1. However, it remains unclear how A20 terminates NF-kappaB signaling downstream of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TNFAIP3 UBE2D3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID