BAIT
EXOC1
BM-102, SEC3, SEC3L1, SEC3P, BM-012
exocyst complex component 1
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CCDC88A
APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212
coiled-coil domain containing 88A
GO Process (10)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- TOR signaling [ISS]
- activation of protein kinase B activity [ISS]
- cell migration [IMP]
- lamellipodium assembly [IMP]
- membrane organization [IDA]
- regulation of DNA replication [ISS]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cell proliferation [ISS]
- regulation of neuron projection development [ISS]
- regulation of protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with cognitive deficits in both schizophrenics and the normal ageing population. In this study, we have generated a network of protein-protein interactions (PPIs) around DISC1. This has been achieved by utilising iterative yeast-two hybrid (Y2H) screens, combined with detailed pathway and functional analysis. This so-called 'DISC1 interactome' contains many ... [more]
Mol. Psychiatry Jan. 01, 2007; 12(1);74-86 [Pubmed: 17043677]
Throughput
- Low Throughput
Curated By
- BioGRID