BAIT
EXOC1
BM-102, SEC3, SEC3L1, SEC3P, BM-012
exocyst complex component 1
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SRGAP2
ARHGAP34, FNBP2, SRGAP2A, SRGAP3, RP11-312O7.2
SLIT-ROBO Rho GTPase activating protein 2
GO Process (14)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- actin filament severing [IDA]
- axon guidance [TAS]
- cell proliferation [IMP]
- dendritic spine development [IDA]
- extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [ISS]
- filopodium assembly [IDA]
- lamellipodium assembly involved in ameboidal cell migration [IMP]
- negative regulation of cell death [IMP]
- negative regulation of neuron migration [IDA]
- neuron projection morphogenesis [ISS]
- positive regulation of Rac GTPase activity [IDA, IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- substrate adhesion-dependent cell spreading [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with cognitive deficits in both schizophrenics and the normal ageing population. In this study, we have generated a network of protein-protein interactions (PPIs) around DISC1. This has been achieved by utilising iterative yeast-two hybrid (Y2H) screens, combined with detailed pathway and functional analysis. This so-called 'DISC1 interactome' contains many ... [more]
Mol. Psychiatry Jan. 01, 2007; 12(1);74-86 [Pubmed: 17043677]
Throughput
- Low Throughput
Curated By
- BioGRID