ARHGEF15
Gene Ontology Biological Process
Gene Ontology Molecular Function
EPHB2
Gene Ontology Biological Process
- angiogenesis [IMP]
- axon guidance [IDA, IMP]
- axonal fasciculation [IMP]
- camera-type eye morphogenesis [IMP]
- cell morphogenesis [IGI]
- central nervous system projection neuron axonogenesis [IMP]
- commissural neuron axon guidance [IMP]
- corpus callosum development [IMP]
- dendritic spine development [IMP]
- dendritic spine morphogenesis [IDA, IMP]
- ephrin receptor signaling pathway [IDA, TAS]
- inner ear morphogenesis [IMP]
- learning [IMP]
- negative regulation of axonogenesis [IDA]
- optic nerve morphogenesis [IMP]
- organ morphogenesis [IMP]
- palate development [IMP]
- peptidyl-tyrosine phosphorylation [IDA, TAS]
- phosphorylation [IDA]
- positive regulation of long-term neuronal synaptic plasticity [IMP]
- positive regulation of synapse assembly [IDA, IMP]
- protein phosphorylation [IDA]
- regulation of axonogenesis [IDA]
- regulation of body fluid levels [IMP]
- regulation of neuronal synaptic plasticity [IMP]
- retinal ganglion cell axon guidance [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
- urogenital system development [IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.
The mechanisms that promote excitatory synapse formation and maturation have been extensively studied. However, the molecular events that limit excitatory synapse development so that synapses form at the right time and place and in the correct numbers are less well understood. We have identified a RhoA guanine nucleotide exchange factor, Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EPHB2 ARHGEF15 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID