BAIT
HSPB1
CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27
heat shock 27kDa protein 1
GO Process (21)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular component movement [TAS]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- gene expression [TAS]
- intracellular signal transduction [IMP]
- mRNA metabolic process [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISS]
- negative regulation of protein kinase activity [ISS]
- platelet aggregation [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood vessel endothelial cell migration [IMP]
- positive regulation of endothelial cell chemotaxis [IMP]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IMP]
- positive regulation of interleukin-1 beta production [ISS]
- positive regulation of tumor necrosis factor biosynthetic process [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- regulation of translational initiation [TAS]
- response to unfolded protein [NAS]
- response to virus [IEP]
- retina homeostasis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TNF
DIF, TNF-alpha, TNFA, TNFSF2, DADB-70P7.1
tumor necrosis factor
GO Process (75)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- activation of MAPK activity [IDA]
- activation of MAPKKK activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- cellular response to nicotine [IDA]
- cellular response to organic cyclic compound [IDA]
- chronic inflammatory response to antigenic stimulus [IMP]
- embryonic digestive tract development [IEP]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA, NAS]
- inflammatory response [IDA]
- leukocyte tethering or rolling [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- necroptotic signaling pathway [IDA]
- negative regulation of branching involved in lung morphogenesis [IDA]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of fat cell differentiation [NAS]
- negative regulation of gene expression [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of lipid catabolic process [IDA]
- negative regulation of lipid storage [NAS]
- negative regulation of protein complex disassembly [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [NAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of calcidiol 1-monooxygenase activity [IDA]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- positive regulation of chemokine biosynthetic process [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of cytokine production [IDA]
- positive regulation of cytokine secretion [IDA]
- positive regulation of fever generation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA]
- positive regulation of interleukin-8 biosynthetic process [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of mononuclear cell migration [NAS]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of podosome assembly [IDA]
- positive regulation of programmed cell death [IDA]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein complex disassembly [IDA]
- positive regulation of protein localization to cell surface [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of protein transport [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vitamin D biosynthetic process [IDA]
- protein import into nucleus, translocation [IDA]
- protein kinase B signaling [IMP]
- receptor biosynthetic process [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of insulin secretion [IDA]
- response to glucocorticoid [IDA]
- response to salt stress [TAS]
- response to virus [IDA]
- sequestering of triglyceride [IDA]
- transformed cell apoptotic process [IDA]
- tumor necrosis factor-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Chaperone Hsp27 modulates AUF1 proteolysis and AU-rich element-mediated mRNA degradation.
AUF1 is an AU-rich element (ARE)-binding protein that recruits translation initiation factors, molecular chaperones, and mRNA degradation enzymes to the ARE for mRNA destruction. We recently found chaperone Hsp27 to be an AUF1-associated ARE-binding protein required for tumor necrosis factor alpha (TNF-α) mRNA degradation in monocytes. Hsp27 is a multifunctional protein that participates in ubiquitination of proteins for their degradation ... [more]
Mol. Cell. Biol. Apr. 01, 2011; 31(7);1419-31 [Pubmed: 21245386]
Throughput
- Low Throughput
Curated By
- BioGRID