BAIT
USP46
ubiquitin specific peptidase 46
GO Process (2)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
WDR77
MEP-50, MEP50, Nbla10071, p44, p44/Mep50, HKMT1069
WD repeat domain 77
GO Process (4)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cytoplasm [IDA, IGI]
- cytosol [IDA, TAS]
- methylosome [IDA]
- nucleoplasm [IDA]
- nucleus [IGI]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.
Post-translational histone modifications play important roles in regulating gene expression programs, which in turn determine cell fate and lineage commitment during development. One such modification is histone ubiquitination, which primarily targets histone H2A and H2B. Although ubiquitination of H2A and H2B has been generally linked to gene silencing and gene activation, respectively, the functions of histone ubiquitination during eukaryote development ... [more]
J. Biol. Chem. Mar. 04, 2011; 286(9);7190-201 [Pubmed: 21183687]
Throughput
- Low Throughput
Curated By
- BioGRID