TMUB1
Gene Ontology Cellular Component
RNF139
Gene Ontology Biological Process
- negative regulation of cell proliferation [IDA]
- negative regulation of translation [IDA]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- protein destabilization [IMP]
- protein ubiquitination [IDA, IMP]
- regulation of ER to Golgi vesicle-mediated transport [IDA]
- regulation of protein processing [IDA]
- regulation of protein ubiquitination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Membrane-associated Ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway in the yeast Saccharomyces cerevisiae is mediated by two membrane-bound ubiquitin ligases, Doa10 and Hrd1. These enzymes are found in distinct multiprotein complexes that allow them to recognize and target a variety of substrates for proteasomal degradation. Although multiprotein complexes containing mammalian ERAD ubiquitin ligases likely exist, they have yet to be identified ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID