A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Condensin association with histone H2A shapes mitotic chromosomes.

Tada K, Susumu H, Sakuno T, Watanabe Y

Chromosome structure is dynamically regulated during cell division, and this regulation is dependent, in part, on condensin. The localization of condensin at chromosome arms is crucial for chromosome partitioning during anaphase. Condensin is also enriched at kinetochores but its precise role and loading machinery remain unclear. Here we show that fission yeast (Schizosaccharomyces pombe) kinetochore proteins Pcs1 and Mde4-homologues of ... [more]

Unknown Jun. 01, 2011; 0(0); [Pubmed: 21633354]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)
phenotype: heat sensitivity (APO:0000147)

Additional Notes

cut3-477 pcs1 double mutant is synthetic lethal at 30 degrees

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CSM1 CUT3	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Tada K (2011)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

CUT3

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

CSM1