A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Condensin association with histone H2A shapes mitotic chromosomes.

Tada K, Susumu H, Sakuno T, Watanabe Y

Chromosome structure is dynamically regulated during cell division, and this regulation is dependent, in part, on condensin. The localization of condensin at chromosome arms is crucial for chromosome partitioning during anaphase. Condensin is also enriched at kinetochores but its precise role and loading machinery remain unclear. Here we show that fission yeast (Schizosaccharomyces pombe) kinetochore proteins Pcs1 and Mde4-homologues of ... [more]

Unknown Jun. 01, 2011; 0(0); [Pubmed: 21633354]

Throughput

Low Throughput

Ontology Terms

phenotype: cell cycle progression in m phase (APO:0000258)

Additional Notes

and decreased condensin localization at kinetochores
h2a.z h2a-R18A double mutants show increased condensation defect, unresolved DNA at anaphase, lagging chromosomes at anaphase

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PHT1 HTA1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Tada K (2011)	Low	-	BioGRID	593103

Curated By

BioGRID

Interaction Summary

PHT1

Gene Ontology Biological Process

Gene Ontology Cellular Component

HTA1