CDC42
Gene Ontology Biological Process
- Cdc42 protein signal transduction [IC]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- intermembrane transport [IMP]
- regulation of barrier septum assembly [IMP]
- regulation of beta-glucan biosynthetic process [IGI]
- regulation of conjugation with cellular fusion [IMP]
- regulation of establishment or maintenance of cell polarity regulating cell shape [IMP]
- regulation of exocytosis [IGI]
- regulation of intracellular protein transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RHO3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Cdc42 regulates multiple membrane traffic events in fission yeast.
Fission yeast Cdc42 regulates polarized growth and is involved in For3 formin activation and actin cable assembly. We show here that a thermosensitive strain carrying the cdc42L160S allele has membrane traffic defects independent of the actin cable defects. This strain has decreased acid phosphatase (AP) secretion, intracellular accumulation of vesicles and fragmentation of vacuoles. In addition, the exocyst is not ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- cdc42L160S rho3 double mutant is synthetically lethal
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC42 RHO3 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 593425 | |
| CDC42 RHO3 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 593422 |
Curated By
- BioGRID