BAIT
IRF6
LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1
interferon regulatory factor 6
GO Process (7)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- cell cycle arrest [IDA]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- mammary gland epithelial cell differentiation [ISS]
- negative regulation of cell proliferation [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
IRF5
SLEB10
interferon regulatory factor 5
GO Process (10)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of apoptotic process [IMP]
- positive regulation of interferon-alpha production [IC]
- positive regulation of interferon-beta production [IC]
- positive regulation of interleukin-12 production [IC]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- response to muramyl dipeptide [IDA]
- response to peptidoglycan [IDA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
To systematically investigate innate immune signaling networks regulating production of type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty-eight baits were associated with 260 interacting proteins forming a human innate immunity interactome for type I interferon (HI5) of 401 unique interactions; 21% of interactions were modulated by RNA, DNA, or LPS. Overexpression and depletion analyses identified 22 ... [more]
Immunity Sep. 23, 2011; 35(3);426-40 [Pubmed: 21903422]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007)
Additional Notes
- exogenous expression of bait
- some interactions identified in this screen were stimulated by the addition of poly(rI:rC), poly(dA:dT), LPS, and/or CpG
Curated By
- BioGRID