BAIT
DHX58
D11LGP2, D11lgp2e, LGP2, RLR-3
DEXH (Asp-Glu-X-His) box polypeptide 58
GO Process (9)
GO Function (4)
GO Component (0)
Gene Ontology Biological Process
- negative regulation of MDA-5 signaling pathway [IMP]
- negative regulation of RIG-I signaling pathway [IDA, IMP]
- negative regulation of innate immune response [IDA]
- negative regulation of type I interferon production [IDA]
- positive regulation of MDA-5 signaling pathway [ISS]
- positive regulation of RIG-I signaling pathway [ISS]
- positive regulation of type I interferon production [ISS]
- regulation of innate immune response [IDA]
- response to virus [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
STAU1
PPP1R150, STAU, RP3-470L14.2
staufen double-stranded RNA binding protein 1
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
To systematically investigate innate immune signaling networks regulating production of type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty-eight baits were associated with 260 interacting proteins forming a human innate immunity interactome for type I interferon (HI5) of 401 unique interactions; 21% of interactions were modulated by RNA, DNA, or LPS. Overexpression and depletion analyses identified 22 ... [more]
Immunity Sep. 23, 2011; 35(3);426-40 [Pubmed: 21903422]
Throughput
- High Throughput
Ontology Terms
- hek-293 cell (BTO:0000007)
Additional Notes
- exogenous expression of bait
- some interactions identified in this screen were stimulated by the addition of poly(rI:rC), poly(dA:dT), LPS, and/or CpG
Curated By
- BioGRID