BAIT
RIPK3
RIP3
receptor-interacting serine-threonine kinase 3
GO Process (30)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell differentiation in thymus [ISS]
- T cell homeostasis [ISS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of protein kinase activity [IMP]
- amyloid fibril formation [IMP]
- apoptotic signaling pathway [TAS]
- cellular protein modification process [TAS]
- innate immune response [TAS]
- lymph node development [ISS]
- necroptotic process [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of necroptotic process [IDA, IMP]
- positive regulation of phosphatase activity [IMP]
- positive regulation of type I interferon production [TAS]
- protein autophosphorylation [IDA]
- protein heterooligomerization [IMP]
- protein homooligomerization [IDA]
- regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [ISS]
- regulation of T cell mediated cytotoxicity [ISS]
- regulation of activated T cell proliferation [ISS]
- regulation of activation-induced cell death of T cells [ISS]
- regulation of adaptive immune response [ISS]
- regulation of interferon-gamma production [ISS]
- signal transduction [TAS]
- spleen development [ISS]
- thymus development [ISS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
FKBP4
FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52
FK506 binding protein 4, 59kDa
GO Process (5)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
To systematically investigate innate immune signaling networks regulating production of type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty-eight baits were associated with 260 interacting proteins forming a human innate immunity interactome for type I interferon (HI5) of 401 unique interactions; 21% of interactions were modulated by RNA, DNA, or LPS. Overexpression and depletion analyses identified 22 ... [more]
Immunity Sep. 23, 2011; 35(3);426-40 [Pubmed: 21903422]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007)
Additional Notes
- exogenous expression of bait
- some interactions identified in this screen were stimulated by the addition of poly(rI:rC), poly(dA:dT), LPS, and/or CpG
Curated By
- BioGRID