BAIT
TLR3
CD283, IIAE2
toll-like receptor 3
GO Process (32)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- I-kappaB phosphorylation [IDA]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of NF-kappaB-inducing kinase activity [NAS]
- cellular response to mechanical stimulus [IEP]
- defense response to bacterium [TAS]
- defense response to virus [TAS]
- detection of virus [NAS]
- extrinsic apoptotic signaling pathway [IDA]
- hyperosmotic response [NAS]
- innate immune response [TAS]
- necroptotic signaling pathway [IDA]
- negative regulation of osteoclast differentiation [NAS]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-alpha biosynthetic process [IDA]
- positive regulation of interferon-beta biosynthetic process [IDA, IMP]
- positive regulation of interferon-beta production [ISS]
- positive regulation of interferon-gamma biosynthetic process [IDA]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of toll-like receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- response to exogenous dsRNA [IDA]
- signal transduction [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TOLLIP
IL-1RAcPIP
toll interacting protein
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
To systematically investigate innate immune signaling networks regulating production of type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty-eight baits were associated with 260 interacting proteins forming a human innate immunity interactome for type I interferon (HI5) of 401 unique interactions; 21% of interactions were modulated by RNA, DNA, or LPS. Overexpression and depletion analyses identified 22 ... [more]
Immunity Sep. 23, 2011; 35(3);426-40 [Pubmed: 21903422]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007)
Additional Notes
- exogenous expression of bait
- some interactions identified in this screen were stimulated by the addition of poly(rI:rC), poly(dA:dT), LPS, and/or CpG
Curated By
- BioGRID