BAIT
DHX58
D11LGP2, D11lgp2e, LGP2, RLR-3
DEXH (Asp-Glu-X-His) box polypeptide 58
GO Process (9)
GO Function (4)
GO Component (0)
Gene Ontology Biological Process
- negative regulation of MDA-5 signaling pathway [IMP]
- negative regulation of RIG-I signaling pathway [IDA, IMP]
- negative regulation of innate immune response [IDA]
- negative regulation of type I interferon production [IDA]
- positive regulation of MDA-5 signaling pathway [ISS]
- positive regulation of RIG-I signaling pathway [ISS]
- positive regulation of type I interferon production [ISS]
- regulation of innate immune response [IDA]
- response to virus [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
DHX30
DDX30, RETCOR
DEAH (Asp-Glu-Ala-His) box helicase 30
GO Process (2)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
To systematically investigate innate immune signaling networks regulating production of type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty-eight baits were associated with 260 interacting proteins forming a human innate immunity interactome for type I interferon (HI5) of 401 unique interactions; 21% of interactions were modulated by RNA, DNA, or LPS. Overexpression and depletion analyses identified 22 ... [more]
Immunity Sep. 23, 2011; 35(3);426-40 [Pubmed: 21903422]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DHX58 DHX30 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 594066 |
Curated By
- BioGRID