BAIT

MIB2

ZZANK1, ZZZ5, RP11-345P4.1
mindbomb E3 ubiquitin protein ligase 2
GO Process (2)
GO Function (3)
GO Component (1)
Homo sapiens

Biochemical Activity (Ubiquitination)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

Li S, Wang L, Berman M, Kong YY, Dorf ME

To systematically investigate innate immune signaling networks regulating production of type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty-eight baits were associated with 260 interacting proteins forming a human innate immunity interactome for type I interferon (HI5) of 401 unique interactions; 21% of interactions were modulated by RNA, DNA, or LPS. Overexpression and depletion analyses identified 22 ... [more]

Immunity Sep. 23, 2011; 35(3);426-40 [Pubmed: 21903422]

Throughput

  • Low Throughput

Additional Notes

  • in the presence of E1, Ubc13 and Uev1a

Curated By

  • BioGRID