BAIT

TGFB1

CED, DPD1, LAP, TGFB, TGFbeta
transforming growth factor, beta 1
GO Process (102)
GO Function (6)
GO Component (11)

Gene Ontology Biological Process

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling.

Wang T, Danielson PD, Li BY, Shah PC, Kim SD, Donahoe PK

The alpha subunit of p21(RAS) farnesyltransferase (FNTA), which is also shared by geranylgeranyltransferase, was isolated as a specific cytoplasmic interactor of the transforming growth factor-beta (TGF-beta) and activin type I receptors with the use of the yeast two-hybrid system. FNTA interacts specifically with ligand-free TGF-beta type l receptor but is phosphorylated and released upon ligand binding. Furthermore, the release is ... [more]

Science Feb. 23, 1996; 271(5252);1120-2 [Pubmed: 8599089]

Throughput

  • Low Throughput

Curated By

  • BioGRID