BAIT

RAC3

ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

GO Process (8)

GO Function (3)

GO Component (10)

Gene Ontology Biological Process

GTP catabolic process [IDA]

actin cytoskeleton organization [IDA]

cell projection assembly [IDA]

intracellular signal transduction [TAS]

positive regulation of cell adhesion mediated by integrin [IDA]

positive regulation of substrate adhesion-dependent cell spreading [IDA]

regulation of small GTPase mediated signal transduction [TAS]

small GTPase mediated signal transduction [TAS]

Gene Ontology Molecular Function

GTPase activity [IDA]
calcium-dependent protein binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

cell periphery [IDA]

endomembrane system [IDA]

extracellular vesicular exosome [IDA]

filamentous actin [IDA]

growth cone [IDA]

neuron projection [IDA]

neuronal cell body [IDA]

perinuclear region of cytoplasm [IDA]

plasma membrane [TAS]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

ARHGDIB

D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2

Rho GDP dissociation inhibitor (GDI) beta

GO Process (9)

GO Function (0)

GO Component (5)

Gene Ontology Biological Process

Rho protein signal transduction [TAS]

actin cytoskeleton organization [TAS]

cellular component movement [TAS]

immune response [TAS]

multicellular organismal development [TAS]

negative regulation of cell adhesion [TAS]

regulation of catalytic activity [TAS]

regulation of small GTPase mediated signal transduction [TAS]

small GTPase mediated signal transduction [TAS]

Gene Ontology Cellular Component

cytoplasm [TAS]

cytoplasmic membrane-bounded vesicle [TAS]

cytoskeleton [TAS]

extracellular vesicular exosome [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A directed protein interaction network for investigating intracellular signal transduction.

Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE

Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]

Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]

Throughput

High Throughput

Curated By

BioGRID