BAIT

CDK5

PSSALRE

cyclin-dependent kinase 5

Alzheimer's Disease Project

GO Process (25)

GO Function (8)

GO Component (10)

Gene Ontology Biological Process

axon extension [TAS]

axon guidance [TAS]

blood coagulation [TAS]

cell proliferation [TAS]

negative regulation of neuron death [IDA]

negative regulation of proteolysis [IMP]

negative regulation of transcription, DNA-templated [IMP]

neuron apoptotic process [TAS]

neuron differentiation [ISS, TAS]

neuron migration [TAS]

neuron projection development [ISS]

oligodendrocyte differentiation [IDA]

peptidyl-serine phosphorylation [IDA]

phosphorylation [IDA]

positive regulation of actin cytoskeleton reorganization [TAS]

positive regulation of neuron apoptotic process [ISS]

regulation of apoptotic process [TAS]

regulation of cell cycle arrest [TAS]

regulation of dendritic spine morphogenesis [ISS]

regulation of synaptic plasticity [ISS, TAS]

regulation of synaptic vesicle recycling [NAS]

synapse assembly [TAS]

synaptic transmission [TAS]

synaptic vesicle endocytosis [TAS]

synaptic vesicle exocytosis [TAS]

Gene Ontology Molecular Function

ErbB-2 class receptor binding [ISS]
ErbB-3 class receptor binding [ISS]
acetylcholine receptor activator activity [ISS]
kinase activity [ISS]
protein binding [IPI]
protein kinase activity [TAS]
protein serine/threonine kinase activity [IDA, ISS, TAS]
tau-protein kinase activity [ISS]

Gene Ontology Cellular Component

cytoplasm [ISS]

growth cone [ISS]

neuromuscular junction [ISS]

neuronal cell body [ISS]

postsynaptic density [ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

ALAS1

ALAS, ALAS3, ALASH, MIG4, OK/SW-cl.121

5'-aminolevulinate synthase 1

GO Process (4)

GO Function (0)

GO Component (4)

Gene Ontology Biological Process

cellular lipid metabolic process [TAS]

heme biosynthetic process [TAS]

porphyrin-containing compound metabolic process [TAS]

small molecule metabolic process [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

mitochondrial matrix [TAS]

mitochondrion [IDA]

nucleoplasm [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A directed protein interaction network for investigating intracellular signal transduction.

Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE

Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]

Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]

Throughput

High Throughput

Curated By

BioGRID