BAIT
BAK1
BAK, BAK-LIKE, BCL2L7, CDN1
BCL2-antagonist/killer 1
GO Process (19)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity [IDA]
- apoptotic process [TAS]
- apoptotic signaling pathway [IMP]
- cellular response to UV [IMP, ISS]
- cellular response to mechanical stimulus [IEP]
- endoplasmic reticulum calcium ion homeostasis [TAS]
- establishment or maintenance of transmembrane electrochemical gradient [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [IBA]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- positive regulation of apoptotic process [IMP]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [TAS]
- positive regulation of proteolysis [IDA]
- regulation of mitochondrial membrane permeability [IDA]
- regulation of mitochondrial membrane potential [IDA]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein homodimerization activity [IDA]
- release of cytochrome c from mitochondria [IDA, IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARHGDIA
GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1
Rho GDP dissociation inhibitor (GDI) alpha
GO Process (10)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- cellular component movement [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [TAS]
- negative regulation of cell adhesion [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of axonogenesis [TAS]
- regulation of axonogenesis [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- semaphorin-plexin signaling pathway [ISS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID