BAIT
MAPK8IP2
IB-2, IB2, JIP2, PRKM8IPL
mitogen-activated protein kinase 8 interacting protein 2
GO Process (14)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- MAPK cascade [IDA]
- behavioral fear response [ISS]
- dendrite morphogenesis [ISS]
- nonassociative learning [ISS]
- positive regulation of protein kinase activity [IDA, IGI]
- positive regulation of signal transduction [NAS]
- regulation of JNK cascade [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of receptor activity [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- signal complex assembly [TAS]
- social behavior [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SYNE2
EDMD5, NUA, NUANCE, Nesp2, Nesprin-2, SYNE-2, TROPH
spectrin repeat containing, nuclear envelope 2
GO Process (5)
GO Function (2)
GO Component (15)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SUN-KASH complex [IDA]
- Z disc [IDA]
- aggresome [IDA]
- cytoplasm [IDA]
- extracellular vesicular exosome [IDA]
- filopodium membrane [IDA]
- focal adhesion [IDA]
- intermediate filament cytoskeleton [IDA]
- lamellipodium membrane [IDA]
- mitochondrion [IDA]
- nuclear envelope [IDA]
- nuclear lumen [IDA]
- nuclear membrane [IDA]
- nucleus [IDA]
- sarcoplasmic reticulum [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID